FTS LyoStar II

FTS LyoStar II™

The LyoStar II® is an R&D and process development freeze-dryer that provides unmatched process accuracy, reliability and unique ease-of-use features. The LyoStar II features RTD-controlled shelf temperature accuracy of +/- 0.5°C or better and vacuum control within 0.1% of set-point. Its robust 5.5 hp cascade refrigeration system enables shelf pull down from ambient to –40°C in less than 25 minutes, and the ultra-reliable scroll compressors feature just 3 moving parts . LyoStar II’s unique integrated arm-mounted touchscreen controls enable the operator to manage and monitor operations at the unit.

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Shelf pull-down rate from ambient to -40ºC in less than 25 minutes
Temperature resolution in 0.1ºC increments
Powerful scroll compressors with only three moving parts (complete with two-year warranty)
Three-year warranty (with the purchase of a preventative maintenance contract)

APPLICATIONS

Process development for scale-up
Product processing for stability studies
Formulation work

Features		Benefits
•	Condenser coil design inside stainless steel housing	•	Provides superior lyophilization efficiency
•	Sealed shelf fluid system	•	Reduces need for frequent refills and minimizes the possibility of contamination
•	RTDs measure temperature	•	Shelf temperature stability and accuracy of ±0.5ºC
•	Touch screen computer	•	Facilitates data entry and cycle monitoring
•	Enhanced cascade refrigeration system	•	Shelf cooling to 70ºC
•	Front panel access door for pump and condenser drain	•	Provides convenient access for easy maintenance
•	Clear acrylic chamber door	•	Provides unobstructed view of product

Bulk System Configurations
Dimensional Specifications
	LYO1B	LYO2B	LYO3B	LYO4B	LYO5B
No. shelves	1	2	3	4	5
Shelf area (sq. ft/m¹)	1.5/0.14	3.1/0.29	4.6/0.43	6.1/0.57	7.6/0.71
Distance between shelves (in./mm)	9.5/241	4.5/114	2.8/71	2.0/51	1.5/38

Volumetric Specifications (Liters)
Product thickness	LYO1B	LYO2B	LYO3B	LYO4B	LYO5B
0.25 in. (0.6 cm)	0.88	1.77	2.66	3.55	4.43
0.50 in. (1.3 cm)	1.77	3.55	5.32	7.09	8.86
0.75 in. (1.9 cm)	2.66	5.32	7.98	10.64	13.29
1.0 in. (2.54 cm)	3.54	7.09	10.64	14.18	17.73

Stoppering System Configurations
Dimensional Specifications
	LYO1S	LYO2S	LYO3S	LYO4S
No. shelves	1	2	3	4
Shelf area (sq. ft./m¹)	1.5/0.14	3.1/0.28	4.6/0.43	6.1/0.57
Distance between shelves (in./mm)	9.5/241	4.5/114	2.8/71	2.0/51

Serum Bottle Dimensions and capacity (Number of bottles processed)
	2 ml	3.5 ml	5 ml	10 ml	20 ml	30 ml	50 ml	1000 ml
Diameter (mm)	17.5	18	23	25	32	37	43	52
Height (mm)¹	43	53	56	63	67	72	82	104
LYO1S	468	459	273	228	135	100	66	45
LYO2S	936	918	546	456	270	200	132	90
LYO3S	1404	1377	819	684	405	200²	132²	90²
LYO4S	1872	1377²	819²	684²	405²	200²	132²	90²
1. Includes partially inserted stopper. 2. Requires shelf latching plates. Each Bulk LyoStar II comes with one solid bottom tray per shelf. Each Stoppering LyoStar II comes with one removable bottom tray per shelf.

Specification Sheet

SMART Freeze-Dryer Technology

SMART Freeze-Dryer Technology is a patented system that puts
the experience of the world’s top lyophilization scientists into an
easy-to-use cycle development tool. Developed exclusively with
leading academics at The University of Connecticut and Purdue
University, this technology is available on the LyoStar II
freeze-dryer (including a retrofit option for existing LyoStar II systems). SMART Freeze-Dryer Technology patent no. 6,971,187 relates to the automated process control of using manometric temperature measurement.

SMART Freeze-Dryer technology eliminates the trial-and-error approach normally involved in developing new lyophilization cycles. It enables experts and novices alike to develop new cycles quickly, while also ensuring that those cycles are elegant and efficient. The SMART tools provide instant feedback on important product data — such as product resistance, heat flow, and product thickness — that was previously unavailable.

SMART Freeze-Dryer Technology frees formulation scientists to focus on formulations.

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